Configure Office365 to send you events in iCalendar format.
Configure how Thunderbird opens a browser when you click a link.
Learn how to get Thunderbird to request a return receipt on an email.
Learn how to disable hardware acceleration in Thunderbird in order to possibly resolve rendering issues/responsiveness.
Learn how to connect Thunderbird to Office 365, once you have enabled 2FA in office 365.
Learn how to use different profiles in Thunderbird. This allows you to easily separate your "work" email accounts from your "personal" email account etc.